Measuring the impact of healthcare on society is an important but unsolved challenge. It has many dimensions, including the direct impact on patient care and its cost as well as the economic growth from new products and services created. In addition, significant value can be created from the knowledge and skills generated. How do some of the leading institutes collect, measure and analyse data and use it to showcase impact? Understanding the key challenges and learning from prior efforts can enrich our own methodologies and help focus future investments where they are likely to create the greatest value while demonstrating our impact on European healthcare.